Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection.

Abstract

Interferon-gamma (IFNgamma)-mediated indoleamine 2,3-dioxygenase (IDO) expression, important in innate immunity, immune suppression, and tolerance, can be counteracted by ferrous iron (FeSO(4)). Elevation of intracellular iron levels during stimulation with IFNgamma impeded IFNgamma-induced IDO mRNA and protein expression in HEp-2 cells. Decreased IDO… (More)
DOI: 10.1016/j.micpath.2009.03.001

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@article{KrausseOpatz2009FreeII, title={Free iron ions decrease indoleamine 2,3-dioxygenase expression and reduce IFNgamma-induced inhibition of Chlamydia trachomatis infection.}, author={Birgit Krausse-Opatz and Ulrike Wittkop and Frank Mathias Gutzki and Cornelia S Schmidt and Barbara J{\"u}rgens-Saathoff and Sabine M Meier and Bibiana Beckmann and Osamu Takikawa and Michael Morgan and Dimitrios Tsikas and Dirk O. Stichtenoth and Annette Doris Wagner and Henning K Zeidler and Lars Koehler}, journal={Microbial pathogenesis}, year={2009}, volume={46 6}, pages={289-97} }