Free insulin-like growth factor-I and breast cancer risk.

  title={Free insulin-like growth factor-I and breast cancer risk.},
  author={Benjamin D. L. Li and Mohammad Javad Khosravi and Hans J. Berkel and Anastasia Diamandi and Mark A. Dayton and Melanie Smith and Herbert Yu},
  journal={International journal of cancer},
  volume={91 5},
Insulin-like growth factor-I (IGF-I) has mitogenic and anti-apoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions of IGF-I are mediated through the IGF-I receptor (IGF-IR) and are regulated by IGFBPs. In circulation, most of the IGF-I binds to IGFBP-3, and binding of IGF-I to IGFBP-3 inhibits the actions of IGF… CONTINUE READING