Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis.

@article{Wilczak2003FreeIG,
  title={Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis.},
  author={Nadine Wilczak and Rob de Vos and Jacques de Keyser},
  journal={Lancet},
  year={2003},
  volume={361 9362},
  pages={1007-11}
}
BACKGROUND Insulin-like growth factor-I (IGF-I) is a potent survival factor for motor neurons and is being investigated as possible therapeutic agent for amyotrophic lateral sclerosis. However, very little information is available on the components of the IGF-I system in this disease. Insulin-like growth factor binding proteins (IGFBPs) play an important part in regulating the bioavailability of IGF-I. METHODS We investigated the components of the IGF-I system in spinal cord sections of ten… CONTINUE READING

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