Free histidine as a metal chelator in plants that accumulate nickel

  title={Free histidine as a metal chelator in plants that accumulate nickel},
  author={Ute Kr{\"a}mer and Janet D. Cotter-Howells and John M. Charnock and Alan John Martin Baker and J. Andrew C. Smith},
A NUMBER of terrestrial plants accumulate large quantities of metals such as zinc, manganese, nickel, cobalt and copper in their shoots1. The largest group of these so-called 'metal hyperaccumulators' is found in the genus Alyssum, in which nickel concentrations can reach 3% of leaf dry biomass2,3. Apart from their intrinsic interest, plants exhibiting this trait could be of value in the decontamination of metal-polluted soils4–6. However, the biochemical basis of the capacity for metal… Expand
Nickel stimulates copper uptake by nickel-hyperaccumulator plants in the genus Alyssum
In the present study, the tolerance, uptake, accumulation and interactions of Ni and copper (Cu) were assessed in a range of Alyssum species and Stimulation of Cu uptake by Ni in the Ni hyperaccumulators hints that this particular feature may be among the characteristics that enable them tohyperaccumulate Ni, unlike their congeneric non-accumulator plants. Expand
Structure and function of metal chelators produced by plants
Plants produce a range of ligands for cadmium (Cd), copper (Cu), nickel (Ni), and zinc (Zn), and these ligands are prevalent in leaves, even though malate is more abundant, and little is known about the counterpart situation for Cu and Zn. Expand
Nickel hyperaccumulation mechanisms: a review on the current state of knowledge
BackgroundHyperaccumulator plants are unusual plants that accumulate particular metals or metalloids, such as nickel, zinc, cadmium and arsenic, in their living tissues to concentrations that areExpand
HISN3 mediates adaptive response of Chlamydomonas reinhardtii to excess nickel.
A biological role is identified for HISN3 (the gene coding for phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide isomerase) in regulating the response of Chlamydomonas reinhardtii, a unicellular green alga, to Ni toxicity. Expand
Transporters of ligands for essential metal ions in plants.
Recent advances in understanding the role of mugineic acid, nicotianamine, organic acid, organic acids, histidine and phytate as ligands for iron (Fe), zinc (Zn), copper (Cu), manganese (Mn) and nickel (Ni) in plants, and the proteins identified as their transporters are reviewed. Expand
Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation
This review extensively summarizes and discusses the current knowledge of the main pathways for the biosynthesis of low-molecular-weight ligands, their involvement in metal uptake, radial and long-distance transport, as well as metal influx, isolation and sequestration in plant tissues and cell compartments. Expand
Possible Molecular Mechanisms Involved in Nickel, Zinc and Selenium Hyperaccumulation in Plants
Phytoextraction, a cost-effective, in situ, plant-based approach to soil remediation takes advantage of the remarkable ability of hyperaccumulating plants to concentrate metals from the soil and accumulate them in their harvestable, above-ground tissues. Expand
Interference of nickel with copper and iron homeostasis contributes to metal toxicity symptoms in the nickel hyperaccumulator plant Alyssum inflatum.
It is suggested that Ni interferes with Cu regulation and that the disruption of root-to-shoot Fe translocation is a major cause of nickel toxicity symptoms in A. inflatum. Expand
Constitutively High Expression of the Histidine Biosynthetic Pathway Contributes to Nickel Tolerance in Hyperaccumulator Plantsw⃞
Results suggest that ATP-PRT expression plays a major role in regulating the pool of free His and contributes to the exceptional Ni tolerance of hyperaccumulator Alyssum species. Expand
Nicotianamine Over-accumulation Confers Resistance to Nickel in Arabidopsis thaliana
A new potential role for nicotianamine in heavy metal tolerance at the cellular but also at the whole plant level is highlighted, easily transposable to a non-tolerant non-hyperaccumulator species. Expand


Accumulation mechanisms and heavy metal tolerance of a nickel hyperaccumulator
Abstract Alyssum bertoionii Desv., a crucifer which grows only in Tuscany on serpentine soil, is characterized by high Ni concentration in its leaves and a high tolerance to this element. In thisExpand
Phytochemical studies suggest that hyperaccumulation is closely linked to the mechanism of metal tolerance involved in the successful colonization of metalliferous and otherwise phytotoxic soils. Expand
Nickel uptake by Alyssum species
Abstract Experiments were carried out on 11 species of Alyssum of which 9 had the capacity to accumulate very high concentrations of nickel. These hyperaccumulators were grown in substratesExpand
Phytochelatins in Cadmium-Sensitive and Cadmium-Tolerant Silene vulgaris (Chain Length Distribution and Sulfide Incorporation)
Although these compounds might play some role in mechanisms that contribute to Cd detoxification, the ability to produce these compounds in greater amounts is not, itself, the mechanism that produces increased Cd tolerance in tolerant S. vulgaris plants. Expand
The chemical form and physiological function of nickel in some Iberian Alyssum species
The chemical evidence suggests that the two hyperaccumulators of Alyssum serpyllifolium are not conspecific and that subsp. Expand
Potential methods for selective accumulation of nickel(II) ions by plants
Abstract The selective uptake of nickel ions by certain plant species is described. The observed selectivity relative to metal ions such as cobalt and iron cannot be explained on the known bindingExpand
Cadmium-Sensitive, cad1 Mutants of Arabidopsis thaliana Are Phytochelatin Deficient
Results demonstrate conclusively the importance of PCs for cadmium tolerance in plants and demonstrate that each mutant was deficient in PC synthase activity. Expand
Phytochelatins: The Principal Heavy-Metal Complexing Peptides of Higher Plants
These peptides appear upon induction of plant cells with heavy metals and represent the principal metal-binding activities in the cells and are proposed as phytochelatin for this new class of natural products. Expand
Poly(gamma-glutamylcysteinyl)glycine Synthesis in Datura innoxia and Binding with Cadmium : Role in Cadmium Tolerance.
The results show that the biosynthetic pathway for (gammaEC)(n)G synthesis in sensitive cells is operational and that relative overproduction of (gamMAEC)( n)G is not the mechanism of Cd-tolerance in a C d-tolerant cell line of D. innoxia. Expand
The possibility of in situ heavy metal decontamination of polluted soils using crops of metal-accumulating plants
The decontamination of soils and wastes polluted with heavy metals presents one of the most intractable problems for soil clean-up. Present technology relies upon metal extraction or immobilizationExpand