Free fetal DNA in maternal plasma in anembryonic pregnancies: confirmation that the origin is the trophoblast.

@article{Alberry2007FreeFD,
  title={Free fetal DNA in maternal plasma in anembryonic pregnancies: confirmation that the origin is the trophoblast.},
  author={Medhat S Alberry and David L Maddocks and Mark Jones and Maha S A Abdel Hadi and Sherif A Abdel-Fattah and N Avent and Peter W. Soothill},
  journal={Prenatal diagnosis},
  year={2007},
  volume={27 5},
  pages={415-8}
}
OBJECTIVE To test the hypothesis that free fetal DNA (ffDNA) circulating in maternal plasma originates mainly from the placenta we studied ffDNA levels in anembryonic pregnancies. METHODS Maternal blood samples were collected from 15 normal first-trimester pregnancies in which fetal sex was subsequently determined and nine patients with a diagnosis of anembryonic gestation (AG). The Y chromosome DYS14 gene was quantified by real-time quantitative PCR (RT-PCR) for the determination of fetal… CONTINUE READING