Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity.

@article{Malhi2007FreeFA,
  title={Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity.},
  author={Harmeet Malhi and Fernando J. Barreyro and Hajime Isomoto and Steven F. Bronk and Gregory James Gores},
  journal={Gut},
  year={2007},
  volume={56 8},
  pages={
          1124-31
        }
}
BACKGROUND Elevated circulating free fatty acids (FFA) contribute to the development of hepatic steatosis and promote hepatocyte apoptosis by incompletely defined mechanisms. Although the death ligand TRAIL has been implicated in a variety of pathological liver diseases, the role of TRAIL in mediating apoptosis of FFA induced steatotic hepatocytes is unknown. AIM We examined TRAIL cytotoxicity in an in vitro model of hepatocyte steatosis induced by FFA. METHODS Hepatocytes (Huh 7 cells… CONTINUE READING
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