Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.

@article{Boden2005FreeFA,
  title={Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver.},
  author={Guenther Boden and Pengxiang She and Maria A Mozzoli and Peter W Cheung and Kiranmai Gumireddy and P. L. Venkata Pakki Reddy and Xiaqin Xiang and Zhijan Luo and Neil Bertrand Ruderman},
  journal={Diabetes},
  year={2005},
  volume={54 12},
  pages={3458-65}
}
To study mechanisms by which free fatty acids (FFAs) cause hepatic insulin resistance, we have used euglycemic-hyperinsulinemic clamping with and without infusion of lipid/heparin (to raise or to lower plasma FFAs) in alert male rats. FFA-induced hepatic insulin resistance was associated with increased hepatic diacylglycerol content (+210%), increased activities of two serine/threonine kinases (protein kinase C-delta and inhibitor of kappaB [IkappaB] kinase-beta), increased activation of the… CONTINUE READING
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