Free fatty acids impair hepatic insulin extraction in vivo.

  title={Free fatty acids impair hepatic insulin extraction in vivo.},
  author={Stephanie R Wiesenthal and Harmanjit Sandhu and Richard H McCall and Vaja Tchipashvili and Hidenori Yoshii and K. Polonsky and Zhi Q. Shi and Gary F. Lewis and Andrea Mari and Adria Giacca},
  volume={48 4},
Hyperinsulinemia is a common finding in obesity and results from insulin hypersecretion and impaired hepatic insulin extraction. In vitro studies have shown that free fatty acids (FFAs), which are often elevated in obesity, can impair insulin binding and degradation in isolated rat hepatocytes. To investigate whether FFAs impair hepatic insulin extraction (E(H)) in vivo, either saline (SAL) or 10% Intralipid (0.03 ml x kg(-1) x min(-1)) plus heparin (0.44 U x kg(-1) x min(-1)) (IH) was infused… CONTINUE READING


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