Free fatty acids as mediators of adaptive compensatory responses to insulin resistance in dexamethasone-treated rats.

@article{Novelli2008FreeFA,
  title={Free fatty acids as mediators of adaptive compensatory responses to insulin resistance in dexamethasone-treated rats.},
  author={Michela Novelli and Alessandro Pocai and Chiara Chiellini and Margherita Maffei and Pellegrino Masiello},
  journal={Diabetes/metabolism research and reviews},
  year={2008},
  volume={24 2},
  pages={155-64}
}
BACKGROUND Chronic low-dose dexamethasone (DEX) treatment in rats is associated to insulin resistance with compensatory hyperinsulinaemia and reduction in food intake. We tested the hypothesis that the elevation in circulating free fatty acids (FFAs) induced by DEX is the common mediator of both insulin resistance and insulin hyperproduction. METHODS For this purpose, an anti-lipolytic agent was administered during DEX treatment to lower lipacidaemia for several hours prior to glucose and… CONTINUE READING

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