Free fatty acids and type 2 diabetes mellitus.

  title={Free fatty acids and type 2 diabetes mellitus.},
  author={Kathleen Louise Wyne},
  journal={The American journal of medicine},
  volume={115 Suppl 8A},
Acute elevation of plasma free fatty acids (FFAs) is necessary for insulin secretion. Sustained elevation, however, leads to apoptosis of pancreatic beta-cells and is a major risk factor for cardiovascular disease and sudden death in patients with insulin resistance or a family history of diabetes mellitus, as well as in individuals with normal glucose tolerance. Data suggest that reduction of FFA plasma levels may reduce the incidence of cardiovascular disease in these at-risk patients… CONTINUE READING