Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.

@article{Iwasaki2015FreeFA,
  title={Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.},
  author={Kanako Iwasaki and Norio Harada and Kazuki Sasaki and Shunsuke Yamane and Keiko Iida and Kazuyo Suzuki and Akihiro Hamasaki and Daniela Nasteska and Kimitaka Shibue and Erina Joo and Takanari Harada and Toshihiro Hashimoto and Yoshinori Asakawa and Akira Hirasawa and Nobuya Inagaki},
  journal={Endocrinology},
  year={2015},
  volume={156 3},
  pages={
          837-46
        }
}
Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells in response to meal ingestion. Recently free fatty acid receptor G protein-coupled receptor (GPR) 120 was identified as a lipid sensor involved in glucagon-like peptide-1 secretion. However, Gpr 120 gene expression and its role in K cells remain unclear, partly due to difficulties in separation of K cells from other intestinal epithelial cells. In this study, we purified K cells using GIP-green fluorescent… 

Figures from this paper

Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice
TLDR
Results indicate that corn oil-induced GIP secretion from K cells involves both GPR120 and GPR40 signaling pathways, and G PR120-inducedGIP secretion is indirectly mediated by CCK.
A novel anti-inflammatory role of GPR120 in intestinal epithelial cells.
TLDR
These studies for the first time demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders.
Carbonic anhydrase 8 (Car8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids.
TLDR
It is found that PPG-cells substantially express carbonic anhydrase 8 (Car8), which has been reported to inhibit inositol 1,4,5-trisphosphate (IP3) binding to the IP3 receptor and subsequent Ca2+ efflux from the endoplasmic reticulum in neuronal cells, and demonstrated that Car8 knockdown increases long-chain fatty acid (LCFA)-stimulated GLP-1 secretion.
The incretin effect After the proposal of ‘ secretin ’ as a blood-borne factor coordinating the arrival of food in the upper small intestine with exocrine pancreatic secretion
TLDR
A systematic summary of the molecular mechanisms underlying secretion from incretin cells, and an understanding of how they sense and interact with lumen and vascular factors and the enteric nervous system through transporters and G-protein coupled receptors present on their surface to ultimately culminate in hormone release is provided.
Mechanisms of fat‐induced gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide secretion from K cells
TLDR
Results suggest that Rfx6 is involved in hypersecretion of GIP in HFD‐induced obese conditions by increasing GIP gene expression.
GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
TLDR
The 2-monoacylglycerol receptor GPR119 is at least as important as the long-chain fatty acid receptor FFA1 in mediating the TG-induced secretion of incretins and that the 2 receptors act in synergy, whereas FFA4 plays a minor if any role.
Free Fatty Acid Receptors in Enteroendocrine Cells.
Free fatty acid receptors (FFAs) are highly enriched in enteroendocrine cells providing pathways to link dietary fats and microbially generated short-chain fatty acids (SCFAs) to the secretion of a
Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract
TLDR
Understanding of the initiating G-protein coupled receptor (GPCR) circuits engaged locally within the intestine and how they become altered with high-fat diet feeding can offer insight into the dysregulation observed in obesity and diabetes.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 55 REFERENCES
Distribution of K and L cells in the feline intestinal tract.
Transcriptional Regulatory Factor X6 (Rfx6) Increases Gastric Inhibitory Polypeptide (GIP) Expression in Enteroendocrine K-cells and Is Involved in GIP Hypersecretion in High Fat Diet-induced Obesity*
TLDR
Results suggest that Rfx6 increases GIP expression and content in K-cells and is involved in GIP hypersecretion in HFD-induced obesity.
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain.
TLDR
GIP receptor localization in the adrenal cortex suggests that it may have effects on glucocorticoid metabolism, and mRNA for the known peptide ligand for the receptor cannot be detected in the brain by in situ hybridization or polymerase chain reaction, suggesting that a novel peptide may be present in thebrain.
Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion
TLDR
Together, the data provide evidence that Gpr40 modulates FFA-stimulated insulin secretion from β-cells not only directly but also indirectly via regulation of incretin secretion and suggest a conserved role for Ipf1/Pdx1 and GPR40 in F FA-mediated secretion of hormones that regulate glucose and overall energy homeostasis.
Immunocytochemical evidence for a paracrine interaction between GIP and GLP-1-producing cells in canine small intestine
TLDR
The results suggest the existence of a paracrine interaction between the K and L cells and indicate the importance of the jejunum in the regulation of insulin release by enteric-derived incretins.
The effect of gastric inhibitory polypeptide on intestinal glucose absorption and intestinal motility in mice.
Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry
TLDR
A strong overlap between upper SI L-, K-, and I-cells is indicated and it is suggested that these cell types may rather comprise a single cell type, within which individual cells exhibit a hormonal spectrum that may reflect factors such as location along the intestine and exposure to dietary nutrients.
A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.
TLDR
GPR119 regulates glucose tolerance by acting on intestinal endocrine cells as well as pancreatic beta-cells, and combined stimulation of incretin hormone release and protection against incRETin hormone degradation may be an effective antidiabetic strategy.
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
TLDR
It is shown that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs and promotes the secretion of GLP-1 in vitro and in vivo, and increases circulating insulin.
Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
TLDR
These transgenic mice and primary culture techniques provide novel opportunities to interrogate the mechanisms of GIP secretion and suggest that targeting appropriate G-protein-coupled receptors may provide opportunities to modulate GIP release in vivo.
...
1
2
3
4
5
...