Free fatty acid receptor 1 (FFA1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion

@article{Salehi2005FreeFA,
  title={Free fatty acid receptor 1 (FFA1R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion},
  author={Albert Salehi and Erik Flodgren and N. E. Lennart Nilsson and Javier Jimenez-Feltstrom and Jun-Ichi Miyazaki and Christer Owman and Bj{\"o}rn Olde},
  journal={Cell and Tissue Research},
  year={2005},
  volume={322},
  pages={207-215}
}
Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release by an intracellular mechanism involving inhibition of CPT-1. The recently de-orphanized G-protein coupled receptor, FFA1R/GPR40, has been shown to be essential for fatty-acid-stimulated insulin release in MIN6 mouse insulinoma cells. The CPT-1 inhibitor, 2-bromo palmitate (2BrP), was investigated for its ability to interact with mouse FFA1R/GPR40. It was found to inhibit phosphatidyl inositol hydrolysis… CONTINUE READING
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