Free energy self-averaging in protein-sized random heteropolymers.

Abstract

Current theories of heteropolymers are inherently macroscopic, but are applied to mesoscopic proteins. To compute the free energy over sequences, one assumes self-averaging--a property established only in the macroscopic limit. By enumerating the states and energies of compact 18, 27, and 36mers on a lattice with an ensemble of random sequences, we test the… (More)
DOI: 10.1103/PhysRevLett.87.078104

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