Free-energy landscape of enzyme catalysis.

@article{Benkovic2008FreeenergyLO,
  title={Free-energy landscape of enzyme catalysis.},
  author={Stephen J Benkovic and Gordon G. Hammes and Sharon Hammes-Schiffer},
  journal={Biochemistry},
  year={2008},
  volume={47 11},
  pages={3317-21}
}
The concept is developed that enzyme mechanisms should be viewed as "catalytic networks" with multiple conformations that occur serially and in parallel in the mechanism. These coupled ensembles of conformations require a multi-dimensional standard free-energy surface that is very "rugged", containing multiple minima and transition states. Experimental and theoretical evidence is presented to support this concept. 

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