Free-energy landscape of a hyperstable RNA tetraloop.

Abstract

We report the characterization of the energy landscape and the folding/unfolding thermodynamics of a hyperstable RNA tetraloop obtained through high-performance molecular dynamics simulations at microsecond timescales. Sampling of the configurational landscape is conducted using temperature replica exchange molecular dynamics over three isochores at high… (More)
DOI: 10.1073/pnas.1603154113

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