Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway.

@article{Kedi2009FreeCO,
  title={Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway.},
  author={Xu Kedi and Yan Ming and Wang Yong-ping and Y. Yi and Z. Xiao-xiang},
  journal={Atherosclerosis},
  year={2009},
  volume={207 1},
  pages={
          123-30
        }
}
  • Xu Kedi, Yan Ming, +2 authors Z. Xiao-xiang
  • Published 2009
  • Medicine, Biology
  • Atherosclerosis
  • OBJECTIVE Smooth muscle cells (SMCs) death promotes atherosclerotic lesion necrosis and plaque destabilization. We investigated the potential mechanisms of rat SMCs death in response to excess free cholesterol (FC). METHODS AND RESULTS Rat aortic SMCs were incubated with "water soluble cholesterol" and acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor Sandoz58035 to establish FC-overloading cell model. Disruption of mitochondrial network and endoplasmic reticulum (ER) was observed after… CONTINUE READING
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