Free carnitine and acylcarnitines in obese patients with polycystic ovary syndrome and effects of pioglitazone treatment.

@article{Vigerust2012FreeCA,
  title={Free carnitine and acylcarnitines in obese patients with polycystic ovary syndrome and effects of pioglitazone treatment.},
  author={Natalya Filipchuk Vigerust and Pavol Bohov and Bodil Bj{\o}rndal and Reinhard Seifert and Ottar K. Nyg{\aa}rd and Asbj{\o}rn Svardal and Dorte Glintborg and Rolf Kristian Berge and Michael Gaster},
  journal={Fertility and sterility},
  year={2012},
  volume={98 6},
  pages={
          1620-6.e1
        }
}

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References

SHOWING 1-10 OF 35 REFERENCES

Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome.

Decreased total L-carnitine levels may be associated with hyperandrogenism and/or insulin resistance in non-obese women with PCOS and long-term studies are needed to evaluate carnitine metabolism in PCOS.

Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome.

Metabolic and hormonal changes induced by pioglitazone in polycystic ovary syndrome: a randomized, placebo-controlled clinical trial.

Compared to placebo, pioglitazone treatment in PCOS was associated with improvements in insulin action and glucose homeostasis and ameliorated the hyperandrogenic ovarian response.

Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome.

Pioglitazone treatment significantly increased GHRH-stimulated GH levels and 24-h pulsatile GH secretion, probably directly or indirectly due to improved insulin sensitivity.

Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome.

Investigating whether the thiazolidinedione derivative pioglitazone diminishes insulin resistance and hyperandrogenism and enhances ovulation rates in women with PCOS resulted in a remarkable decline in both fasting serum insulin levels and the area under the insulin response curve after an oral glucose load.

Carnitine palmitoyltransferase I deficiency in neonate identified by dried blood spot free carnitine and acylcarnitine profile

A neonate at risk for hepatic carnitine palmitoyltransferase I (L-CPT I) deficiency was investigated from birth and an isolated elevation of free carnitines only in an apparently healthy term neonate warrants further investigation.

Hepatic carnitine palmitoyltransferase I deficiency: acylcarnitine profiles in blood spots are highly specific.

ESI-MS/MS provides a highly specific acylcarnitine profile from dried-blood samples that is highly specific for CPT-I deficiency and may allow presymptomatic diagnosis, as well as providing a guidance for electrospray ionization-tandem mass spectrometry diagnosis.

Low serum carnitine in HIV-infected children on antiretroviral treatment

Serum free and total carnitine, acylcarnitines, methionine and lysine were significantly lower in HIV-infected children compared with the authors' reference values for similar ages, suggestingMalabsorption or defective synthesis may also account for the low serum carnItine values detected in these patients.

Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity

This study focused on characterizing AcylCN profiles in human plasma from individuals with obesity and T2DM during fasting and insulin‐stimulated conditions, suggesting that more fatty acids can enter mitochondria.