Free Radicals as Mediators of Neuronal Injury

  title={Free Radicals as Mediators of Neuronal Injury},
  author={Fabrizio Facchinetti and Valina L Dawson and Ted M Dawson},
  journal={Cellular and Molecular Neurobiology},
1. Free radicals may play an important role in several pathological conditions of the central nervous system (CNS) where they directly injure tissue and where their formation may also be a consequence of tissue injury. 2. Free radicals produce tissue damage through multiple mechanisms, including excitotoxicity, metabolic dysfunction, and disturbance of intracellular homeostasis of calcium. 3. Oxidative stress can significantly worsen acute insults, such as ischemia, as well as chronic… CONTINUE READING


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