• Corpus ID: 51903777

Free Radicals and Oxidative Stress in Neurodegenerative Diseases : Relevance of Dietary Antioxidants

@inproceedings{Singh2004FreeRA,
  title={Free Radicals and Oxidative Stress in Neurodegenerative Diseases : Relevance of Dietary Antioxidants},
  author={Ravindra Pratap Singh and Shashwat Sharad and Suman Kapur},
  year={2004}
}
Cellular antioxidants are known to change their redox state, and they can be targeted for destruction, regulate oxidative processes involved in signal transduction, effect gene expression and pathways of cell proliferation and death. Oxidants and antioxidants play an important role in maintaining a balance between free radicals produced by metabolism or derived from environmental sources and the antioxidant system of the body. A complex natural antioxidant system exists in the biological… 

Tables from this paper

Free Radicals, Antioxidants in Disease and Health
TLDR
This mini-review deals with the taxonomy, the mechanisms of formation and catabolism of the free radicals, it examines their beneficial and deleterious effects on cellular activities, and it highlights the potential role of the antioxidants in preventing and repairing damages caused by oxidative stress.
Use of natural antioxidants to scavenge free radicals: a major cause of diseases.
TLDR
The present review article is an attempt to generate interest and awareness that, free radical is a major cause of many diseases.
Battle between plants as antioxidants with free radicals in human body
TLDR
This paper seeks to report the available evidence about oxidative stress and the application of plants as antioxidant agents to fight free radicals in the human body and the role of herbs and diet in oxidative stress.
Oxidative Stress: Harms and Benefits for Human Health
TLDR
In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
Oxidative damage and carcinogenesis
TLDR
Oxygen is an essential element to conduct life processes but some of the metabolic byproducts e.g. reactive oxygen species, are toxic for living organisms and ROS are considered as a significant class of carcinogens participating in cancer initiation, promotion and progression.
Oxidative Stress-Induced Response of Some Endogenous Antioxidants in Schizophrenia
TLDR
Chronic schizophrenics were at a higher risk of oxidative stress and age and substance abuse seems to worsen the situation, and the response and role of some endogenous antioxidants viz. reduced glutathione, bilirubin, total proteins, albumin and uric acid in scavenging the ROS is highlighted.
Natural Antioxidants for Health
TLDR
This review aims to provide a literature survey on how the Natural Antioxidants are used with respect to oxidation of cells.
Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions
TLDR
Direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety is focused on and different opinions that exist in this field are discussed, highlighting the importance of oxidative Stress in the etiology, incidence, progression, and prevention of psychiatric disorders.
Free Radicals, Oxidative Stress and Diseases An Overview
TLDR
The harmful effect of free radicals is neutralized by antioxidants, which prevents oxidative damage by reacting with free radicals, therefore, the best remedy is to increase the intake of natural antioxidant.
OXIDA TS A D HUMA DISEASES: ROLE OF A TIOXIDA T MEDICI AL PLA TS-A REVIEW
TLDR
A list of some major role of medicinal plants with potent antioxidant activity have been reviewed against chronic diseases induced by oxidative stress and the evidence of their roles in preventing disease is reviewed.
...
...

References

SHOWING 1-10 OF 45 REFERENCES
Oxidative stress in neurodegeneration: mechanisms and therapeutic perspectives.
TLDR
The present paper shortly summarizes the main sources of free radical production in the brain and reviews some of the recent data on mechanisms of cellular transduction through which free radicals are believed to damage cells and, eventually, to bring them to death.
The Role of Free Radicals in Toxicity and Disease
  • S. Stohs
  • Medicine, Biology
    Journal of basic and clinical physiology and pharmacology
  • 1995
TLDR
The cellular sources of free radicals and reactive oxygen species, the biological targets offree radicals, and clinical conditions which are associated with free radical production and tissue damage are reviewed.
An update on the role of free radicals and antioxidant defense in human disease
TLDR
The role of oxygen free radicals and the activation of the antioxidant systems in arteriosclerosis and ageing, diabetes, ischemia/reperfusion injury, ethanol intoxication, and liver steatosis is discussed.
Role of Free Radicals in the Neurodegenerative Diseases
TLDR
Little is known about the impact of dietary antioxidants upon the development and progression of neurodegenerative diseases, especially Alzheimer’s disease, but there are many attempts to develop antioxidants that can cross the blood-brain barrier and decrease oxidative damage.
Reactive oxygen species as mediators of tissue protection and injury.
TLDR
The oxidant stress induced dysfunction of various systems, such as the gut, airways, nervous, cardiovascular system, etc., involve both direct and indirect mechanisms and understanding of these molecular mechanisms is essential for a rational antioxidant therapy.
Reactive oxygen species and oxidative DNA damage.
TLDR
A high rate of oxidative damage to mammalian DNA has been demonstrated by measuring oxidized DNA bases excreted in urine after DNA repair, directly related to the metabolic rate and inversely related to life span of the organism.
...
...