Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future

@article{Gutteridge2000FreeRA,
  title={Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future},
  author={John M. C. Gutteridge and Barry Halliwell},
  journal={Annals of the New York Academy of Sciences},
  year={2000},
  volume={899}
}
Abstract: In the late 1950's free radicals and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology. Daniel Gilbert, Rebeca Gerschman and their colleagues related the toxic effects of elevated oxygen levels on aerobes to those of ionizing radiation, and proposed that oxygen toxicity is due to free radical formation, in a pioneering paper in 1956. Biochemistry owes… 
REACTIVE OXYGEN SPECIES (ROS): A REVIEW
In the late 1950's free radicals and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and
Free radicals and antioxidants: updating a personal view.
This article looks back to the antioxidant/free radical field in 1994 and discusses how it has progressed in the past 18 years. In some areas, there has been little change: the role of oxygen
HERBAL REMEDIES AS ANTIOXIDANTS: AN OVERVIEW
TLDR
Because free radical damage accumulates with age, people should start supplementing with antioxidants early to achieve long-term benefits and the scientific community has begun to unveil some of the mysteries surrounding this topic.
DNA Damage, a Biomarker of Carcinogenesis: Its Measurement and Modulation by Diet and Environment
  • E. Hwang, P. Bowen
  • Biology, Chemistry
    Critical reviews in food science and nutrition
  • 2007
TLDR
The objective of this review is to discuss the biological significance of oxidative DNA damage, evaluate the effectiveness of several techniques for measurement of oxidativeDNA damage in various biological samples and review current research on factors that influence DNA oxidative damage using these techniques.
The wanderings of a free radical.
Antioxidants in wild mushrooms.
TLDR
The antioxidant properties of wild mushrooms have been extensively studied, and many antioxidant compounds extracted from these sources have been identified, such as phenolic compounds, tocopherols, ascorbic acid, and carotenoids.
Antioxidant Activity of Vitamin E and Trolox: Understanding of the Factors that Govern Lipid Peroxidation Studies In Vitro
Peroxidation of lipids is of significant interest owing to the evidence that peroxyl radicals and products of lipid peroxidation may be involved in the toxicity of compounds initiating a
Therapeutic Uses of Antioxidant Liposomes
TLDR
This chapter focuses on the use of antioxidant liposomes in the general area of free radical biology and medicine, and the role of antioxidants in health and disease.
The Role of Liposomal Antioxidants in Oxidative Stress
TLDR
This review focuses on the use of liposomes for the delivery of antioxidants in the prevention or treatment of several pathological conditions linked to oxidative stress.
Proline Alters Antioxidant Enzyme Defenses and Lipoperoxidation in the Erythrocytes and Plasma of Rats: In Vitro and In Vivo Studies
TLDR
Data indicate that proline alters antioxidant defenses and induces lipid peroxidation in the blood of rats and also increases TBARS in the plasma of rats.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 65 REFERENCES
Will the 'good fairies' please prove to us that vitamin E lessens human degenerative disease?
TLDR
By improving human diets by increasing the quantity in them of antioxidants, it might be possible to reduce the incidence of a number of degenerative diseases and improve substantially the quality of human life, in particular for people of advancing years.
Free radicals in biology and medicine
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related 'reactive species' 3. Antioxidant defences Endogenous and Diet Derived
Chemical determination of free radical-induced damage to DNA.
  • M. Dizdaroglu
  • Biology, Chemistry
    Free radical biology & medicine
  • 1991
Superoxide accelerates DNA damage by elevating free-iron levels.
  • K. Keyer, J. Imlay
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
TLDR
It is striking that both growth defects and DNA damage caused by superoxide ensue from its ability to damage a subset of iron-sulfur clusters.
The Complex Chemistry of Peroxynitrite Decomposition: New Insights1
The yield of hydroxyl radicals produced in the decomposition of peroxynitrous acid (HOONO) at room temperature in deoxygenated and bicarbonate free water at pH ∼6.8 has been determined to be roughly
Establishing the significance and optimal intake of dietary antioxidants: the biomarker concept.
TLDR
The use of biomarkers provides a logical scientific basis for major intervention trials of antioxidants; such trials will, in turn, eventually validate or disprove the biomarker concept.
Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein).
TLDR
The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
...
1
2
3
4
5
...