Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future

  title={Free Radicals and Antioxidants in the Year 2000: A Historical Look to the Future},
  author={John M. C. Gutteridge and Barry Halliwell},
  journal={Annals of the New York Academy of Sciences},
Abstract: In the late 1950's free radicals and antioxidants were almost unheard of in the clinical and biological sciences but chemists had known about them for years in the context of radiation, polymer and combustion technology. Daniel Gilbert, Rebeca Gerschman and their colleagues related the toxic effects of elevated oxygen levels on aerobes to those of ionizing radiation, and proposed that oxygen toxicity is due to free radical formation, in a pioneering paper in 1956. Biochemistry owes… 
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