Free Radicals Are Formed in the Brain of Fetal Sheep during Reperfusion after Cerebral Ischemia

@article{Bgenholm1998FreeRA,
  title={Free Radicals Are Formed in the Brain of Fetal Sheep during Reperfusion after Cerebral Ischemia},
  author={Ralph B{\aa}genholm and Ulf S. Nilsson and Cecilia Wallin G{\"o}tborg and Ingemar Kjellmer},
  journal={Pediatric Research},
  year={1998},
  volume={43},
  pages={271-275}
}
Free radical production in the brain of acutely anesthetized, exteriorized lamb fetuses (n = 11, gestational age = 135 d) was measured using spin trap methodology. Communications between the vertebral and carotid circulations were tied, producing a two-vessel supply to the brain. Flow probes and occlusion slings were placed around each carotid. The spin trap 2-ethyl-3-hydroxy-2,4,4-trimethyloxazolidine (OXANOH) was infused intermittently into one carotid at a constant rate, and blood samples… CONTINUE READING
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