Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators

@inproceedings{Shafi2015FreeLO,
  title={Free Levels of Selected Organic Solutes and Cardiovascular Morbidity and Mortality in Hemodialysis Patients: Results from the Retained Organic Solutes and Clinical Outcomes (ROSCO) Investigators},
  author={Tariq Shafi and Timothy W. Meyer and Thomas H. Hostetter and Michal Melamed and Rulan S. Parekh and Seungyoung Hwang and Tanushree Banerjee and Josef Coresh and Neil R. Powe},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND AND OBJECTIVES Numerous substances accumulate in the body in uremia but those contributing to cardiovascular morbidity and mortality in dialysis patients are still undefined. We examined the association of baseline free levels of four organic solutes that are secreted in the native kidney - p-cresol sulfate, indoxyl sulfate, hippurate and phenylacetylglutamine - with outcomes in hemodialysis patients. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS We measured these solutes in… CONTINUE READING

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Searching for uremic toxins.

Clinical journal of the American Society of Nephrology : CJASN • 2013
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