Free Drug Metabolic Clearance in Elderly People

@article{Butler2008FreeDM,
  title={Free Drug Metabolic Clearance in Elderly People},
  author={Jennifer M. Butler and Evan James Begg},
  journal={Clinical Pharmacokinetics},
  year={2008},
  volume={47},
  pages={297-321}
}
The question of whether metabolic drug clearance is decreased in elderly people has been the subject of considerable debate and is very important because clearance is a determinant of dosing. Drug clearance has been shown to be consistently impaired for flow-limited (high-clearance) drugs, but there have been conflicting results for capacity-limited (low-clearance) drugs. A limitation of the studies of capacity-limited drugs is that most have estimated clearance based on total drug… 

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Review on pharmacokinetics and pharmacodynamics and the aging kidney.

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Clinical pharmacokinetics of antiretroviral drugs in older persons

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