Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals

@inproceedings{Errico2014FreeDR,
  title={Free D-aspartate regulates neuronal dendritic morphology, synaptic plasticity, gray matter volume and brain activity in mammals},
  author={Francesco Errico and Robert Nistic{\`o} and Annabella Di Giorgio and Marta Squillace and Daniela Vitucci and Alberto Galbusera and Sonia Piccinin and Dalila Mango and Laura De Fazio and Silvia Middei and S Trizio and Nicola Biagio Mercuri and Martine Ammassari Teule and Diego Centonze and Alessandro Gozzi and Giuseppe Blasi and Alessandro Bertolino and Alessandro Usiello},
  booktitle={Translational Psychiatry},
  year={2014}
}
D-aspartate (D-Asp) is an atypical amino acid, which is especially abundant in the developing mammalian brain, and can bind to and activate N-methyl-D-Aspartate receptors (NMDARs). In line with its pharmacological features, we find that mice chronically treated with D-Asp show enhanced NMDAR-mediated miniature excitatory postsynaptic currents and basal cerebral blood volume in fronto-hippocampal areas. In addition, we show that both chronic administration of D-Asp and deletion of the gene… CONTINUE READING
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