Free Ca2+ requirements of agonist-induced thromboxane A2 synthesis in human platelets.

Abstract

In quin2-loaded human platelets ionomycin raised cytosolic free calcium to greater than 1 microM and generated less than 1 ng thromboxane. Collagen alone or in the presence of EPO92 generated up to 32 and 16 ng thromboxane respectively; in the latter case at calcium levels around 120 nM. Thrombin maximally raised calcium to greater than 1 microM and… (More)

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Cite this paper

@article{Pollock1986FreeCR, title={Free Ca2+ requirements of agonist-induced thromboxane A2 synthesis in human platelets.}, author={Wendy K Pollock and Richard Irvine and Trenton Rink}, journal={European journal of pharmacology}, year={1986}, volume={132 2-3}, pages={309-12} }