Free Brick1 Is a Trimeric Precursor in the Assembly of a Functional Wave Complex


BACKGROUND The Wave complex activates the Arp2/3 complex, inducing actin polymerization in lamellipodia and membrane ruffles. The Wave complex is composed of five subunits, the smallest of which, Brick1/Hspc300 (Brk1), is the least characterized. We previously reported that, unlike the other subunits, Brk1 also exists as a free form. PRINCIPAL FINDINGS… (More)
DOI: 10.1371/journal.pone.0002462


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