Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.

  title={Free 3-nitrotyrosine causes striatal neurodegeneration in vivo.},
  author={Michael J. Mihm and Brandon L. Schanbacher and Benjamin Wallace and Lane J. Wallace and Norman J. Uretsky and John Anthony Bauer},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 11},
Peroxynitrite formation has been demonstrated in several neurodegenerative disorders; thus far, protein nitration and consequent alterations in protein function are implicated as mechanistic events. Free 3-nitrotyrosine (free-3NT) is also elevated in these settings; a neurotoxic role for this modified amino acid has not been investigated. We tested the hypothesis that free-3NT is neurotoxic in vivo, using a mouse model of striatal degeneration. The neurodegenerative effects of the dopaminergic… CONTINUE READING