Fraying at the edge mouse models of diseases resulting from defects at the nuclear periphery.

@article{Cohen2008FrayingAT,
  title={Fraying at the edge mouse models of diseases resulting from defects at the nuclear periphery.},
  author={Tatiana V Cohen and Colin Lawson Stewart},
  journal={Current topics in developmental biology},
  year={2008},
  volume={84},
  pages={351-84}
}
Eukaryotic cells compartmentalize their genetic material within the nucleus. The boundary separating the genetic material from the cytoplasm is the nuclear envelope (NE) and lamina. Historically, the NE was perceived as functioning primarily as a barrier regulating the entry and exit of macromolecules between the nucleus and cytoplasm via the nuclear pore complexes (NPCs) that traverse the nuclear membranes. However, recent findings have caused a fundamental reassessment with regard to NE and… CONTINUE READING

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