Francisella tularensis reveals a disparity between human and mouse NLRP3 inflammasome activation.

@article{Atianand2011FrancisellaTR,
  title={Francisella tularensis reveals a disparity between human and mouse NLRP3 inflammasome activation.},
  author={Maninjay K. Atianand and Ellen B Duffy and Aaloki Shah and Supriya Kar and Meenakshi Malik and Jonathan A Harton},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 45},
  pages={39033-42}
}
Pathogen-triggered activation of the inflammasome complex leading to caspase-1 activation and IL-1β production involves similar sensor proteins between mouse and human. However, the specific sensors used may differ between infectious agents and host species. In mice, Francisella infection leads to seemingly exclusive activation of the Aim2 inflammasome with no apparent role for Nlrp3. Here we examine the IL-1β response of human cells to Francisella infection. Francisella strains exhibit… CONTINUE READING
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