Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan.

Abstract

Francisella tularensis is a facultative intracellular bacterium that infects many cell types, including neutrophils. We demonstrated previously that F. tularensis inhibits NADPH oxidase assembly and activity and then escapes the phagosome to the cytosol, but effects on other aspects of neutrophil function are unknown. Neutrophils are short-lived cells that… (More)
DOI: 10.4049/jimmunol.1102863

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Cite this paper

@article{Schwartz2012FrancisellaTI, title={Francisella tularensis inhibits the intrinsic and extrinsic pathways to delay constitutive apoptosis and prolong human neutrophil lifespan.}, author={Justin Todd Schwartz and Jason H. Barker and Justin Kaufman and Drew Clair Fayram and Jenna M. McCracken and Lee-Ann H Allen}, journal={Journal of immunology}, year={2012}, volume={188 7}, pages={3351-63} }