Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice.

@article{Wickstrum2009FrancisellaTI,
  title={Francisella tularensis induces extensive caspase-3 activation and apoptotic cell death in the tissues of infected mice.},
  author={Jason R Wickstrum and Sirosh M. Bokhari and Jeffrey L Fischer and David M. Pinson and Hung-Wen Yeh and Rebecca Thayer Horvat and Michael J. Parmely},
  journal={Infection and immunity},
  year={2009},
  volume={77 11},
  pages={4827-36}
}
Although Francisella tularensis subsp. tularensis is known to cause extensive tissue necrosis, the pathogenesis of tissue injury has not been elucidated. To characterize cell death in tularemia, C57BL/6 mice were challenged by the intranasal route with type A F. tularensis, and the pathological changes in infected tissues were characterized over the next 4 days. At 3 days postinfection, well-organized inflammatory infiltrates developed in the spleen and liver following the spread of infection… CONTINUE READING