Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication.

Abstract

The murine macrophage-like cell line J774.A1 ingests and allows intracellular growth of Francisella tularensis. We demonstrate that, after 24 h of infection, a pronounced cytopathogenicity resulted and the J774 cells were undergoing apoptosis. Despite this host cell apoptosis, no decrease in bacterial numbers was observed. When internalization of bacteria… (More)

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Cite this paper

@article{Lai2001FrancisellaTI, title={Francisella tularensis induces cytopathogenicity and apoptosis in murine macrophages via a mechanism that requires intracellular bacterial multiplication.}, author={Xiao Hong Lai and Igor Golovliov and Anders Sj{\"{o}stedt}, journal={Infection and immunity}, year={2001}, volume={69 7}, pages={4691-4} }