Francisella tularensis induces aberrant activation of pulmonary dendritic cells.

  title={Francisella tularensis induces aberrant activation of pulmonary dendritic cells.},
  author={Catharine M. Bosio and Steven Dow},
  journal={Journal of immunology},
  volume={175 10},
Francisella tularensis is an obligate intracellular bacterium that induces severe, acute, often fatal disease when acquired by the respiratory route. Despite the seriousness of this pathogen, very little is understood about its interaction with key target cells in the airways and lungs (alveolar macrophages and airway dendritic cells (DC)) after inhalation. In this study we demonstrate replication of F. tularensis in primary DC. Early after infection, F. tularensis induced increased expression… CONTINUE READING

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