Francisella tularensis Uses Cholesterol and Clathrin-Based Endocytic Mechanisms to Invade Hepatocytes

@inproceedings{Law2011FrancisellaTU,
  title={Francisella tularensis Uses Cholesterol and Clathrin-Based Endocytic Mechanisms to Invade Hepatocytes},
  author={Hong T Law and Ann En-Ju Lin and Youra Kim and Brian Quach and Francis E Nano and Julian A Guttman},
  booktitle={Scientific reports},
  year={2011}
}
Francisella tularensis are highly infectious microbes that cause the disease tularemia. Although much of the bacterial burden is carried in non-phagocytic cells, the strategies these pathogens use to invade these cells remains elusive. To examine these mechanisms we developed two in vitro Francisella-based infection models that recapitulate the non-phagocytic cell infections seen in livers of infected mice. Using these models we found that Francisella novicida exploit clathrin and cholesterol… CONTINUE READING

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