Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro.

@article{Loegering2006FrancisellaTL,
  title={Francisella tularensis LVS grown in macrophages has reduced ability to stimulate the secretion of inflammatory cytokines by macrophages in vitro.},
  author={Daniel J. Loegering and James R. Drake and Jeffrey A Banas and Tamara L McNealy and Debbie G Mc Arthur and Laura M Webster and Michelle R. Lennartz},
  journal={Microbial pathogenesis},
  year={2006},
  volume={41 6},
  pages={218-25}
}
The virulence of Francisella tularensis LVS is determined in part by its ability to invade and replicate within macrophages and stimulate the production of inflammatory cytokines. The present study determined the effects of growing F. tularensis in macrophages on its ability to stimulate cytokine secretion by macrophages. F. tularensis grown in Mueller-Hinton broth (FtB) stimulated the secretion of large amounts of TNF-alpha, IL-12p40, IL-6 and MCP-1/CCL2 when incubated with macrophages… CONTINUE READING