Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS.

@article{Dueas2006FrancisellaTL,
  title={Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS.},
  author={Ana Isabel Due{\~n}as and M{\'o}nica Aceves and Antonio Ordu{\~n}a and R. Graciani Diaz and Mariano S{\'a}nchez Crespo and C{\'a}rmen Garcia-Rodriguez},
  journal={International immunology},
  year={2006},
  volume={18 5},
  pages={785-95}
}
Francisella tularensis is a virulent Gram-negative intracellular pathogen. To address the signaling routes involved in the response of host cells to LPS from F. tularensis live vaccine strain (LVS), experiments were performed in transiently transfected 293 cells. Induction of kappaB-driven transcriptional activity by 2.5 mug ml(-1) F. tularensis LPS isolated by phenol-water and ether-water extraction, was observed in cells transfected with Toll-like receptor (TLR) 4 and MD-2, although CD14 was… CONTINUE READING