Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity.

@article{Shakerley2016FrancisellaTC,
  title={Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity.},
  author={Nicole L Shakerley and Akshaya Chandrasekaran and Mohamed Trebak and Barbara Ann Miller and Juan Andres Melendez},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 8},
  pages={3871-81}
}
As an innate defense mechanism, macrophages produce reactive oxygen species that weaken pathogens and serve as secondary messengers involved in immune function. The Gram-negative bacterium Francisella tularensis utilizes its antioxidant armature to limit the host immune response, but the mechanism behind this suppression is not defined. Here we establish that F. tularensis limits Ca(2+) entry in macrophages, thereby limiting actin reorganization and IL-6 production in a redox-dependent fashion… CONTINUE READING
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