Francisella infection triggers activation of the AIM2 inflammasome in murine dendritic cells.

Abstract

The intracellular bacterium Francisella tularensis is the causative agent of tularemia, a potentially fatal disease. In macrophages, Francisella escapes the initial phagosome and replicates in the cytosol, where it is detected by the cytosolic DNA sensor AIM2 leading to activation of the AIM2 inflammasome. However, during aerosol infection, Francisella is… (More)
DOI: 10.1111/j.1462-5822.2011.01700.x

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