Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response.

@article{Parsa2008FrancisellaGA,
  title={Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response.},
  author={Kishore V. L. Parsa and Jonathan P Butchar and Murugesan V. S. Rajaram and Thomas John Cremer and John S Gunn and Larry S. Schlesinger and Susheela Tridandapani},
  journal={Molecular immunology},
  year={2008},
  volume={45 12},
  pages={
          3428-37
        }
}
Tularemia is a zoonotic disease caused by the Gram-negative intracellular pathogen Francisella tularensis. These bacteria evade phagolysosomal fusion, escape from the phagosome and replicate in the host cell cytoplasm. IFNgamma has been shown to suppress the intra-macrophage growth of Francisella through both nitric oxide-dependent and -independent pathways. Since Francisella is known to subvert host immune responses, we hypothesized that this pathogen could interfere with IFNgamma signaling… CONTINUE READING
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