Framework models of tumor dormancy from patient-derived observations.

  title={Framework models of tumor dormancy from patient-derived observations.},
  author={Christoph A Klein},
  journal={Current opinion in genetics & development},
  volume={21 1},
Unusually long latency periods between the treatment of primary tumors and metastatic recurrences are commonly thought to prove the existence and relevance of clinical tumor dormancy. However, careful consideration of disease courses and cancer growth rates leads to the conclusion that clinical dormancy may be everything from non-existent to much more frequent than originally thought. On the other hand, cellular dormancy defined as a non-productive state of disseminated tumor cells is very… CONTINUE READING

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