Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism

  title={Framework and resource for more than 11,000 gene-transcript-protein-reaction associations in human metabolism},
  author={Jae Yong Ryu and Hyun Uk Kim and Sang Yup Lee},
  journal={Proceedings of the National Academy of Sciences},
  pages={E9740 - E9749}
  • J. Ryu, H. Kim, S. Lee
  • Published 24 October 2017
  • Biology
  • Proceedings of the National Academy of Sciences
Significance Alternative splicing is a regulatory mechanism by which multiple protein isoforms can be generated from one gene. Despite its biological importance, there has been no systematic approach that facilitates characterizing functional roles of protein isoforms in human metabolism. To this end, we present a systematic framework for the generation of gene-transcript-protein-reaction associations (GeTPRA) in human metabolism. The framework involves a generic human genome-scale metabolic… 

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