Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: potency of responses and relationship to slipped mispairing models.

@article{Hoffmann2003FrameshiftMI,
  title={Frameshift mutations induced by three classes of acridines in the lacZ reversion assay in Escherichia coli: potency of responses and relationship to slipped mispairing models.},
  author={George R. Hoffmann and Margaret A. Calciano and Bryan M Lawless and Kathleen M M Mahoney},
  journal={Environmental and molecular mutagenesis},
  year={2003},
  volume={42 2},
  pages={111-21}
}
The frameshift mutagenicity of 9-aminoacridine (9AA) was compared with that of quinacrine, the acridine mustards ICR-191 and quinacrine mustard (QM), and the nitroacridine Entozon in the lacZ reversion assay in Escherichia coli. As intercalating agents, 9AA and quinacrine cause mutations through noncovalent associations with DNA. Mustards and nitroacridines form covalent adducts in DNA and give rise to different spectra of mutations. Quinacrine and 9AA most effectively induced -1 frameshifts in… CONTINUE READING

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Structure - activity relationships for the mutagenic activity of tricyclic intercalating agents in Salmonella typhimurium

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