Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability.

@article{Yamada2002FrameshiftMI,
  title={Frameshift mutations in the MBD4/MED1 gene in primary gastric cancer with high-frequency microsatellite instability.},
  author={Tatsuya Yamada and Toru Koyama and Susumu Ohwada and Ken-ichi Tago and Ichiro Sakamoto and Sumihiko Yoshimura and Kunihiro Hamada and Izumi Takeyoshi and Yasuo Morishita},
  journal={Cancer letters},
  year={2002},
  volume={181 1},
  pages={115-20}
}
MBD4/MED1 is a newly identified mismatch repair gene, which is mutated in colon, endometrial, and pancreatic high-frequency microsatellite instability (MSI-H) tumors. To assess its role in gastric cancers, we investigated MBD4/MED1 mutations in sporadic gastric cancers, compared with colon cancers. Frameshift mutations were found in 29% of gastric and 20… CONTINUE READING