Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype

@article{Yamamoto2000FrameshiftMI,
  title={Frameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype},
  author={Hiroyuki Yamamoto and Joan Gil and Sim{\'o} Schwartz and M. Herma Perucho},
  journal={Cell Death and Differentiation},
  year={2000},
  volume={7},
  pages={238-239}
}
In a letter to the editor in a recent issue of Cell Death and Differentiation, Abdel-Rahman et al. reported the absence of mutations in the death pathways gene Fas (Apo-1/CD95) in colorectal carcinomas. From the absence of mutations in 24 colon cancers, 12 of which were classified as replication error positive (RER+), Abdel-Rahman et al. concluded that such mutations confer no substantial growth advantage in colorectal carcinogenesis. In agreement with this report, we identified Fas mutations… CONTINUE READING

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Curr . Opin . Oncol

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