Frameshift mutation in the Dok1 gene in chronic lymphocytic leukemia

@article{Lee2004FrameshiftMI,
  title={Frameshift mutation in the Dok1 gene in chronic lymphocytic leukemia},
  author={Sanghoon Lee and François Roy and Carlos M Galmarini and Rosita Accardi and Jocelyne Michelon and Alexandra Viller and Eric Teissier du Cros and Charles Dumontet and Bakary S. Sylla},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={2287-2297}
}
B-cell chronic lymphocytic leukemia (B-CLL) is a malignant disease characterized by an accumulation of monoclonal CD5+ mature B cells, with a high percentage of cells arrested in the G0/G1 phase of the cell cycle, and a particular resistance toward apoptosis-inducing agents. Dok1 (downstream of tyrosine kinases) is an abundant Ras-GTPase-activating protein (Ras-GAP)-associated tyrosine kinase substrate, which negatively regulates cell proliferation, downregulates MAP kinase activation and… CONTINUE READING
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