Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma.

@article{ElShazly2006FraktalkinePB,
  title={Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma.},
  author={Amr El-Shazly and Patrick Berger and P. O. Girodet and Olga Ousova and Michael Fayon and Jean-Marc Vernejoux and Roger Marthan and J M Tunon-de-lara},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={1860-8}
}
Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the concentration of which is increased in asthmatic patients. HASMC also induce mast cell chemotaxis, as a component of asthma inflammation. We therefore evaluated the role of smooth muscle-derived FKN in mast cell migration. We assessed the capacity of recombinant FKN to induce human mast cell chemotaxis. This effect implicates a calcium-independent pathway involving actin reorganization and protein kinase C-delta… CONTINUE READING
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