Frailty in people aging with human immunodeficiency virus (HIV) infection.

@article{Brothers2014FrailtyIP,
  title={Frailty in people aging with human immunodeficiency virus (HIV) infection.},
  author={Thomas D Brothers and Susan A. Kirkland and Giovanni Guaraldi and Julian M Falutz and Olga Theou and Barbara Johnston and Kenneth Rockwood},
  journal={The Journal of infectious diseases},
  year={2014},
  volume={210 8},
  pages={
          1170-9
        }
}
The increasing life spans of people infected with human immunodeficiency virus (HIV) reflect enormous treatment successes and present new challenges related to aging. Even with suppression of viral loads and immune reconstitution, HIV-positive individuals exhibit excess vulnerability to multiple health problems that are not AIDS-defining. With the accumulation of multiple health problems, it is likely that many people aging with treated HIV infection may be identified as frail. Studies of… 
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118 Citations
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118 Citations

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Frailty: a new vulnerability indicator in people aging with HIV
TLDR
The clinical care of people aging with HIV could benefit from a focus on frailty and related social vulnerability to better understand patients’ needs and develop appropriate goals and care plans.
The interplay between frailty and intrinsic capacity in aging and HIV infection.
TLDR
A new framework to assess health in PLWH is suggested, shifting from an infectious diseases/internal medicine approach, which includes quality of life in the definition of healthy living with HIV, to an ID/geriatric Medicine approach, focused on the maintenance of functional ability in frail and geriatric PLWH.
Understanding Frailty, Aging, and Inflammation in HIV Infection
TLDR
The current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection are provided.
Older HIV-infected adults: complex patients— geriatric syndromes (II)
TLDR
The final objective is to stress how the only way for adequately tackling the multifaceted frailty condition of people with HIV is to implement novel models of care based on the comprehensive geriatric assessment.
Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV.
TLDR
An opportunity to apply knowledge from geriatric population research to people aging with HIV to better appreciate the complexity of their health status is defined, as frailty is associated with the likelihood of SCA in people living with HIV.
Frailty in people living with HIV
  • M. Bloch
  • Medicine
    AIDS Research and Therapy
  • 2018
TLDR
Physicians who care for PLHIV need to recognise and manage frailty in this patient population, including an understanding of when to intervene aggressively in the management of an older patient with a new HIV diagnosis to delay or prevent permanent debility and frailty.
Aging with HIV
TLDR
This review suggests that geriatric approach should be used to recognize the complexity of aging goes beyond the viro-immunological success and management of progressive accumulation of non-communicable diseases and requires recognition of frailty and geriatric syndromes to stratify patients’ diversity by using comprehensive geriatric assessment tools.
Multimorbidity and Burden of Disease.
  • T. Brown, G. Guaraldi
  • Medicine, Biology
    Interdisciplinary topics in gerontology and geriatrics
  • 2017
TLDR
With aggressive risk factor management for comorbidities and less toxic antiretroviral medications, the burden of multimorbidity in HIV-infected persons can be reduced.
Biologic aging, frailty, and age-related disease in chronic HIV infection.
TLDR
The aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection are reviewed.
Frailty among HIV-1 Infected Adults under Antiretroviral Therapy in Indonesia
TLDR
Frailty is a common occurrence among HIV-infected patients under antiretroviral therapy in Indonesia, with depression as an independent predictive factor.
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TLDR
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TLDR
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