Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study

@article{Tajar2011FrailtyIR,
  title={Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study},
  author={Abdelouahid Tajar and Matthew D. L. O’Connell and Arnold Mitnitski and Terence W. O’Neill and Samuel D Searle and Ilpo Tapani Huhtaniemi and Joseph D. Finn and Gyorgy B{\'a}rtfai and Steven Boonen and Felipe F. Casanueva and Gianni Forti and Aleksander Giwercman and Thang Sieu Han and Krzysztof Kula and Fernand Labrie and Michael E. J. Lean and Neil Pendleton and Margus Punab and Alan J Silman and Dirk Vanderschueren and Kenneth Rockwood and Frederick C W Wu},
  journal={Journal of the American Geriatrics Society},
  year={2011},
  volume={59}
}
OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. 
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  • 2014
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TLDR
Lower 25(OH)D and higher PTH levels were positively associated with frailty in older men and Prospective data would enable the temporal nature of this relationship to be explored further.
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The associations between DHEA and DHEAS and falls are only partially mediated via muscle mass, muscle strength, and/or balance, which suggests that older men with high DHEa or DHEas levels have a lesser likelihood of a fall.
Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer
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Positive associations were observed between the severity of frailty syndrome and estrone, FSH and LH concentrations and the aromatase activity index in the blood (p < 0.05).
Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?
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The effects of androgen treatment in elderly males will be of particular interest in this review, and the current state for the use of T and DHEA therapy in men for the age-related conditions is examined.
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The objective is to determine whether testosterone (T) levels are associated with frailty or its components and to investigate the role of testosterone in frailty and its components.
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The relationship between accumulated health‐related problems (deficits), which define a frailty index in older adults, and mortality in population‐based and clinical/institutional‐based samples is investigated.
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