Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study

  title={Frailty in Relation to Variations in Hormone Levels of the Hypothalamic–Pituitary–Testicular Axis in Older Men: Results From the European Male Aging Study},
  author={Abdelouahid Tajar and Matthew D. L. O’Connell and Arnold Mitnitski and Terence W. O’Neill and Samuel D Searle and Ilpo Tapani Huhtaniemi and Joseph D. Finn and Gyorgy B{\'a}rtfai and Steven Boonen and Felipe F. Casanueva and Gianni Forti and Aleksander Giwercman and Thang Sieu Han and Krzysztof Kula and Fernand Labrie and Michael E. J. Lean and Neil Pendleton and Margus Punab and Alan J Silman and Dirk Vanderschueren and Kenneth Rockwood and Frederick C W Wu},
  journal={Journal of the American Geriatrics Society},
OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men. 
Natural history, risk factors and clinical features of primary hypogonadism in ageing men: Longitudinal Data from the European Male Ageing Study
The natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism in ageing men, including testosterone decline accompanied by elevated luteinizing hormone (LH), are described.
Elevated luteinizing hormone despite normal testosterone levels in older men—natural history, risk factors and clinical features
Elevated luteinizing hormone (LH) with normal testosterone (T) suggests compensated dysregulation of the gonadal axis. We describe the natural history, risk factors and clinical parameters associated
Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing
Potential associations between genetic variants of four genes involved in the cholesterol transport and inflammatory pathway and the frailty index are shown, providing further support for the involvement of the immunological processes in frailty of the elderly.
Androgen Deficiency as a Biological Determinant of Frailty: Hope or Hype?
  • J. Afilalo
  • Medicine, Biology
    Journal of the American Geriatrics Society
  • 2014
A number of potential biases were found in the current body of evidence, including misclassification bias, selection bias, and residual confounding (due to correlation of low testosterone with several disease states and adverse health characteristics), which are vital to ensure that future epidemiological studies and interventional trials generate valid conclusions.
Androgen effects on skeletal muscle: implications for the development and management of frailty
Important future directions include the use of these agents in combination with exercise training to promote functional ability across different populations of older adults, as well as more focus on the relationships between concurrent changes in hormone levels, body composition and physical function in observational studies.
The association of frailty with serum 25-hydroxyvitamin D and parathyroid hormone levels in older European men.
Lower 25(OH)D and higher PTH levels were positively associated with frailty in older men and Prospective data would enable the temporal nature of this relationship to be explored further.
Serum DHEA and Its Sulfate Are Associated With Incident Fall Risk in Older Men: The MrOS Sweden Study
  • C. Ohlsson, M. Nethander, L. Vandenput
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2018
The associations between DHEA and DHEAS and falls are only partially mediated via muscle mass, muscle strength, and/or balance, which suggests that older men with high DHEa or DHEas levels have a lesser likelihood of a fall.
Plasma Aromatase Activity Index, Gonadotropins and Estrone Are Associated with Frailty Syndrome in Post-Menopausal Women with Breast Cancer
Positive associations were observed between the severity of frailty syndrome and estrone, FSH and LH concentrations and the aromatase activity index in the blood (p < 0.05).
Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set?
The effects of androgen treatment in elderly males will be of particular interest in this review, and the current state for the use of T and DHEA therapy in men for the age-related conditions is examined.


Testosterone, Sex Hormone–Binding Globulin, and Frailty in Older Men
The objective is to determine whether testosterone (T) levels are associated with frailty or its components and to investigate the role of testosterone in frailty and its components.
Inflammation and Frailty in Older Women
To evaluate relationships between white blood cell (WBC) count and interleukin‐6 (IL‐6) and prevalent frailty, a large number of animals were vaccinated for WBC and IL‐6 infection.
Relative Fitness and Frailty of Elderly Men and Women in Developed Countries and Their Relationship with Mortality
The relationship between accumulated health‐related problems (deficits), which define a frailty index in older adults, and mortality in population‐based and clinical/institutional‐based samples is investigated.
Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study.
CONTEXT The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear. OBJECTIVE The objective of the study was to investigate the relationships between
Cumulative Index of Health Deficiencies as a Characteristic of Long Life
The accumulation of aging‐associated health disorders is described using a cumulative measure known as a frailty index and its ability to differentiate long‐ and short‐life phenotypes as well as the FI's connection to aging-associated processes in older people is evaluated.
Luteinizing hormone and different genetic variants, as indicators of frailty in healthy elderly men.
Serum LH levels increases with age in independently living elderly men and correlates inversely with a variety of indicators of frailty, which suggests that LH reflects serum androgen activity in a different way than T, possibly reflecting more closely the combined feedback effect of estrogen and androgen.
Low free testosterone predicts frailty in older men: the health in men study.
Lower free testosterone was independently associated with frailty at baseline and follow-up, and Randomized trials should explore whether testosterone therapy can prevent the development of frailty.
Hypogonadism in elderly men--what to do until the evidence comes.
  • P. Snyder
  • Medicine, Biology
    The New England journal of medicine
  • 2004
The Institute of Medicine Committee on Assessing the Need for Clinical Trials of Testosterone Replacement Therapy issued its long-awaited report, which concluded that there is insufficient evidence that testosterone treatment benefits elderly men.
Frailty in older adults: insights and interventions.
Frail older adults are among the most challenging for medical management, but awareness of this syndrome and its risks can help care for them more confidently and decrease their risk for adverse outcomes.
Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty
Frail subjects have lower levels of serum IGF-I and DHEA-S and higher levels of IL-6 than do non-frail, age-matched individuals, suggests potential interaction between endocrine and immune/cytokine dysregulation that requires further study in larger cohorts.