Fragmentation of the 95,000-dalton transmembrane polypeptide in human erythrocyte membranes.

@article{Drickamer1976FragmentationOT,
  title={Fragmentation of the 95,000-dalton transmembrane polypeptide in human erythrocyte membranes.},
  author={L K Drickamer},
  journal={The Journal of biological chemistry},
  year={1976},
  volume={251 17},
  pages={5115-23}
}
  • L K Drickamer
  • Published 1976 in The Journal of biological chemistry
The 95,000-dalton polypeptide in human red blood cell membranes constitutes about 25% of the membrane protein. Previous labeling studies have shown that different regions of this polypeptide are exposed to the inside and outside of the cell and have suggested a role for the protein in anion exchange across the membrane. This polypeptide has been fragmented by chymotrypsin digestion of intact red cells and by treatment of purified polypeptide with 2-nitro-5-thiocyanobenzoic acid, hydroxylamine… CONTINUE READING