Corpus ID: 2810530

Fragmentation of deoxyribonucleic acid by bleomycin.

  title={Fragmentation of deoxyribonucleic acid by bleomycin.},
  author={C. W. Haidle},
  journal={Molecular pharmacology},
  volume={7 6},
  • C. W. Haidle
  • Published 1971
  • Biology, Medicine
  • Molecular pharmacology
The ability of the antibiotic bleomycin to cause single- as well as double-strand breaks in deoxyribonucleic acid in vitro has been confirmed. Heat-denatured, single-stranded DNA is considerably more sensitive to the action of bleomycin than is native DNA. The rate of the reaction of DNA breakage by bleomycin is enhanced in the presence of 2-mercaptoethanol; however, 2-mercaptoethanol also inactivates bleomycin. This inactivation reaction is especially rapid at 80°, although bleomycin itself is… Expand
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